Karen Salomé completed her undergraduate studies in Physics at the Facultad de Ciencias de la UNAM and pursued her doctoral studies at the Karlsruhe Institute of Technology (KIT) in Germany, specializing in Astroparticle Physics. She conducted postdoctoral research at Pennsylvania State University, USA, where she worked on the IceCube and HAWC experiments. Subsequently, she served as a postdoctoral researcher at the University of Santiago de Compostela, Spain, focusing on the Pierre Auger experiment. She also held a postdoctoral position at CINVESTAV-Zacatenco, working on the Pierre Auger and HAWC experiments.

She is an active member of several scientific collaborations, including Pierre Auger, HAWC, Escaramujo, MATHUSLA, SWGO, and LAGO. She was awarded one of the "Scholarships for Women in Science" by L'OREAL México, CONACyT, UNESCO, CONALMEX, and AMC. She has held prominent roles within the Mexican Society of Physics (SMF), serving as President of the Division of Particles and Fields and Secretary of the Division of Cosmic Rays. Additionally, she was the Director of the Facultad de Ciencias en Física y Matemáticas de la Universidad Autónoma de Chiapas (FCFM-UNACH).

Currently, Karen Salomé is a full-time professor and researcher at FCFM-UNACH and serves as the Deputy General Coordinator of MCTP-UNACH. She is a co-task leader for education and outreach in the Pierre Auger Collaboration and represents Mexico in this collaboration. She is also a Level 2 member of the Sistema Nacional de Investigadores and a member of the Academia Mexicana de Ciencias (AMC).